Substance induced mood disorder is a kind of mental disorder where usage or stoppage of a certain drug leads to prominent changes in mood. The mood swings induced by such drugs may persist for days, weeks or even for months. Many drugs are assumed to cause the feelings of despair, depression and hopelessness. The illegal drugs are assumed to be the main culprits and hence most studied in regard to emotional changes.

The first remarkable link between the mood swings and drugs was considered in early 50s when patients taking reserpine complained about the frequent mood alterations. Each drug has its own mechanism for inducing the mood changes. Some patients can develop this mood disorder just in the beginning of drug consumption, while in some other cases drugs can elicit this effect when patient stops consuming the drug. This potent connection between body and drug can have adverse effects on daily life of patient. The sufferers of this mood disorder may also experience some difficulty in controlling their actions.

What Substances Can Cause SIMDs?

Although, there is sufficient data available related to drug induced mood disorders, yet very little data is present on the subject of specific drugs which trigger this disorder. The most commonly known drugs, linked with mood changes are:

  • Interferon-alpha
  • Corticosteroids
  • Digitalis
  • Antidepressants
  • Isotertinoin
  • Methyldopa
  • Clonidene
  • H2 blockers
  • Finasteride

In addition to the above mentioned drugs, there are also many other drugs that are being studied to confirm their possible adverse effects on moods. The withdrawal symptoms are among the most commonly noticed effects triggered by many such drugs. Substances such as alcohol, cocaine, sedatives and narcotics have a very strong withdrawal effect, which ultimately leads to a severe substance related mood disorder. However, as a word of caution it must be taken into consideration that if patient has been diagnosed with depression or related mood swings before taking a drug then related mood changes are not a substance induced mood disorder.